Structure of PDB 7c7a Chain E Binding Site BS01

Receptor Information
>7c7a Chain E (length=145) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRLKSRYILFEIIFPPTDTNVEESVSKADILLSHHRASPADVSIKSILQE
IRRSLSLNLGDYGSAKCNSLLQLKYFSNKTSTGIIRCHREDCDLVIMALM
LMSKIGDVDGLIVNPVKVSGTIKKIEQFAMRRNSKILNIIKCSQS
Ligand information
>7c7a Chain A (length=330) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aauccaugaccaaagaaucgucacaaaucgaagcuuacaaaauggaguaa
aauuuuguuuacucaguaauaugcuuuggguugaaagucucccaccaauu
cguaugcggaaaacguaaugagauuuaaaaaaauuguuuaaaucaacuca
uuaaggaggaugcccuuggguauucugcuucuugaccugguaccucuauu
gcaggguacugguguuuucuucgguacuggauuccguuuguauggaaucu
aaaccauaguuaugacgauugcucuuucccgugcuggaucgaguaaccca
auggagcuuacuauucuugguccauggauu
<<<<<<<<<<<<<<.<<<<<<<......<<<<<<..........<<<<<<
<......>>>>>>>........>>>>>>........[.((((.<<<....
.....<<<.....>>><<<<<..........................>>>
>><<<.<<<<<<<<....>>>>>>>>.>>>......<<<<<<<<<.....
...>>>>>>>>>..........>>>...<<<<<<<<......>>>>>>>>
.............>>>>>>><<<<..<<<......>>>..>>>>......
..)))).]...>....>>>>>>.>>>>>>>
Receptor-Ligand Complex Structure
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PDB7c7a Structural insight into precursor ribosomal RNA processing by ribonuclease MRP.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		R3 K5 R7 K118 S120 K124 K125 R132 K136
Binding residue
(residue number reindexed from 1)		R2 K4 R6 K117 S119 K123 K124 R131 K135
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0000171 ribonuclease MRP activity
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0033204 ribonuclease P RNA binding
Biological Process
GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent
GO:0000460 maturation of 5.8S rRNA
GO:0001682 tRNA 5'-leader removal
GO:0006364 rRNA processing
GO:0008033 tRNA processing
GO:0034965 intronic box C/D snoRNA processing
Cellular Component
GO:0000172 ribonuclease MRP complex
GO:0005634 nucleus
GO:0005655 nucleolar ribonuclease P complex
GO:0005737 cytoplasm
GO:0030677 ribonuclease P complex
GO:1902555 endoribonuclease complex
GO:1990904 ribonucleoprotein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7c7a, PDBe:7c7a, PDBj:7c7a
PDBsum7c7a
PubMed32586950
UniProtP28005|POP5_YEAST Ribonuclease P/MRP protein subunit POP5 (Gene Name=POP5)

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