Structure of PDB 7bre Chain E Binding Site BS01
Receptor Information
>7bre Chain E (length=163) Species:
9606
(Homo sapiens) [
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STRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEM
VIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARF
INHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIESNKLP
CNCGAKRCRRFLN
Ligand information
>7bre Chain F (length=19) Species:
9606
(Homo sapiens) [
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KELDENVEYEERESEFDIE
Receptor-Ligand Complex Structure
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PDB
7bre
Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.
Resolution
2.803 Å
Binding residue
(original residue number in PDB)
K2570 E2603 S2605 G2606 I2607 V2608 R2610 V2612 L2613 R2617 H2644 G2645
Binding residue
(residue number reindexed from 1)
K20 E53 S55 G56 I57 V58 R60 V62 L63 R67 H94 G95
Enzymatic activity
Enzyme Commision number
2.1.1.364
: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB
RCSB:7bre
,
PDBe:7bre
,
PDBj:7bre
PDBsum
7bre
PubMed
32697937
UniProt
Q9UMN6
|KMT2B_HUMAN Histone-lysine N-methyltransferase 2B (Gene Name=KMT2B)
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