Structure of PDB 7aqs Chain E Binding Site BS01

Receptor Information

>7aqs Chain E (length=159) Species: 83333 (Escherichia coli K-12)

SKATNLLYTRNDVSDSEKKATVELLNRQVIQFIDLSLITKQAHWNMRGAN
FIAVHEMLDGFRTALIDHLDTMAERAVQLGGVALGTTQVINSKTPLKSYP
LDIHNVQDHLKELADRYAIVANDVRKAIGEAKDDDTADILTAASRDLDKF
LWFIESNIE

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 7aqs Chain E Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7aqs Identification of a Dps contamination in Mitomycin-C-induced expression of Colicin Ia.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): D78 E82
• Binding residue (residue number reindexed from 1): D70 E74
• Annotation score: 5

Enzymatic activity

• Enzyme Commision number: 1.16.-.-

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005515 protein binding
• GO:0008199 ferric iron binding
• GO:0016491 oxidoreductase activity
• GO:0016722 oxidoreductase activity, acting on metal ions
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006879 intracellular iron ion homeostasis
• GO:0006950 response to stress
• GO:0030261 chromosome condensation
• GO:0032297 negative regulation of DNA-templated DNA replication initiation
• GO:0042594 response to starvation

Cellular Component

• GO:0005737 cytoplasm
• GO:0009295 nucleoid
• GO:0016020 membrane
• GO:1990084 DnaA-Dps complex

External links

• PDB: RCSB:7aqs, PDBe:7aqs, PDBj:7aqs
• PDBsum: 7aqs
• PubMed: 33775657
• UniProt: P0ABT2|DPS_ECOLI DNA protection during starvation protein (Gene Name=dps)