Structure of PDB 7a0v Chain E Binding Site BS01

Receptor Information
>7a0v Chain E (length=317) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKR
SKPTDIFAIGFEEMVELNAGSASTTNQKLWAVELQKTISRDNKYVLLASE
QLVGVCLFVFIRPQHAPFIRDVAVDTVKTGATGNKGAVAIRMLFHTTSLC
FVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHDYVFWCGDFNYR
IDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTY
KYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWLYTWTPGTLLHYGRAELKT
SDHRPVVALIDIDIFEV
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain7a0v Chain E Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7a0v A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations.
Resolution2.3 Å
Binding residue
(original residue number in PDB)
K785 R800
Binding residue
(residue number reindexed from 1)
K251 R266
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.36: phosphoinositide 5-phosphatase.
Gene Ontology
Molecular Function
GO:0016791 phosphatase activity
Biological Process
GO:0046856 phosphatidylinositol dephosphorylation

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Molecular Function

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Biological Process
External links
PDB RCSB:7a0v, PDBe:7a0v, PDBj:7a0v
PDBsum7a0v
PubMed33349335
UniProtO43426|SYNJ1_HUMAN Synaptojanin-1 (Gene Name=SYNJ1)

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