Structure of PDB 6zxh Chain E Binding Site BS01

Receptor Information

>6zxh Chain E (length=255) Species: 9606 (Homo sapiens)

ARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNR
LKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRL
IYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPD
PLIKVNDTIQIDLETGKITDFIKFDTGNLCMVTGGANLGRIGVITNRERH
PGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEE
RDKRL

Ligand information

>6zxh Chain 2 (length=1651)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggcuacagugaaacugcgaauggcucauuaa
aucaguuaugguuccuuuggucgcucguacuuggauaacugugguaauuc
uagagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugc
gugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgcgc
ggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagucgc
cgugccuaccauggugaccacgggugacggggaaucaggguucgauuccg
gagagggagccugagaaacggcuaccacauccaaggaaggcagcaggcgc
gcaaauuacccacucccgacccggggagguagugacgaaaaauaacaaua
caggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauccuu
uaacgaggauccauuggagggcaagucuggugccagcagccgcgguaauu
ccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucguagu
uggaucucucucggccgaagcguuuacuuugaaaaaauuagaguguucaa
agcaggccgccuggauaccgcagcuaggaauaauggaauaggaccgcggu
ucucggaacugaggccaugauuaagagggacggccgggggcauucguauu
gcgccgcuagaggugaaauucuuggaccggcgcaagacggaccagagcga
aagcauuugccaagaauguuuucauuaaucaagaacgaaagucggagguu
cgaagacgaucagauaccgucguaguuccgaccauaaacgaugccgaccg
gcgaugcggcggcguuauaugacccgccgggcagcuuccgggaaaccaaa
gucuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaa
uugacggaagggcaccaccaggaguggagccugcggcuuaauuugacuca
acacgggaaaccucacccggcccggacacggacaggauugacagauugau
agcucuuucucgauuccgugggugguggugcauggccguucuuaguuggu
ggagcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcu
aacuaguuacgcgacccccggucggcguaacuucuuagagggacaagugg
cguucagccacccgagauugagcaauaacaggucugugaugcccuuagau
guccggggcugcacgcgcgcuacacugacuggcucagcgugugccuaccc
uacgccggcaggcgcggguaacccguugaaccccauucgugauggggauc
ggggauugcaauuauuccccaugaacgaggaauucccaguaagugcgggu
cauaagcuugcguugauuaagucccugcccuuuguacacaccgcccgucg
cuacuaccgauuggaugguuuagugaggcccucggaucggccccgccggg
gugcccuggcggagcgcugagaagacggucgaacuugacuaucuagagga
aguaaaagucguaacaagguuuccguagguaaaccugcggaaggaucauu
a

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<.......>>...>>.>>......<<..<...
..<<<.<....<<....<<<<..........<<.....<<.<<<.....>
>>.>>......>>.........<<<<...<<<<<.....>>.>>>...>>
>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<..>
>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<....
.....>>>>>>>>>>......>>>...<<<.<<<<....>>>>....>>>
>>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>>..
.......<<<....<<<<...>>>>..>>>..>...>>.>.....<<<<<
<<<<.<<<....>>>..>>>>>>.>>>......<<..<...........>
..>>.........<<<<<((....<.<<<<.....<<..))>>.......
>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<...<<
<.<<...<<.<<<..>>>>>...<<<<<<.<.......<<...<......
.>.<<<<.>>>>...>>......>.>>>..>>>........<.<<.<<<<
<<...>>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<
<<<<<<...<<<......>>>......>>>>>>>>..>>.......<<..
..>>...>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...
<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<
<<..<.<<<<<<.<<<<<>>>>>>>>>>>.>..>>>...<<..))>>...
>>.....>>>.>.>.<<<......<<<......>>>....>>>..)))).
]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<.....
...>>..........<<<<<......<<<<<<.......<<.<<<.....
...>>>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<
<<<....>>>...<<<......>>>...>>.>>>....<<<...<...<<
<<..<<<<<<<<<<<<...>>>>.>>>>>>>>..>>>>..>.....<<<<
<.....>>>>>........>>>....>>>.>>>.....>>>>>>>>....
..>>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<
<.<<<<....>>>>.>>>....>.........>>>.>>............
<<<<<..........>>>>>...........>>>>>.....<<<<<<<<.
......>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.
.<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<.<<
<..>>>.>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.
>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>........
.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zxh Structural basis for the final steps of human 40S ribosome maturation.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): A2 R3 G4 P5 K6 K7 H8 K10 V12 K16 M19 D21 K22 L23 V26 F27 P29 R30 T33 G34 K37 R49 G58 K62 M66 R77 Y82 K106 R108 K128 V131 G132 K134 G135 A144 T146 R148 K155 G186 A187 H201 G203 A219 R221 R240
• Binding residue (residue number reindexed from 1): A1 R2 G3 P4 K5 K6 H7 K9 V11 K15 M18 D20 K21 L22 V25 F26 P28 R29 T32 G33 K36 R48 G57 K61 M65 R76 Y81 K105 R107 K127 V130 G131 K133 G134 A143 T145 R147 K154 G185 A186 H200 G202 A218 R220 R239

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0008284 positive regulation of cell population proliferation
• GO:0042274 ribosomal small subunit biogenesis
• GO:0045727 positive regulation of translation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0005925 focal adhesion
• GO:0015935 small ribosomal subunit
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:0032040 small-subunit processome
• GO:0036464 cytoplasmic ribonucleoprotein granule
• GO:0045202 synapse
• GO:0070062 extracellular exosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zxh, PDBe:6zxh, PDBj:6zxh
• PDBsum: 6zxh
• PubMed: 33208940
• UniProt: P62701|RS4X_HUMAN Small ribosomal subunit protein eS4, X isoform (Gene Name=RPS4X)