Structure of PDB 6zww Chain E Binding Site BS01

Receptor Information

>6zww Chain E (length=731) Species: 562 (Escherichia coli)

TFTALQQRLDSLMLRDRLRFSRRLHPDAQQAIFQEMAKEIDQAAGKVLLR
EAARPEITYPDNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKIC
MELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKVRFSDHV
SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLK
ELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPID
DTERDQLQAIFDAVDELSQESHGDILIFMSGEREIRDTADALNKLNLRHT
EILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGT
ARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFL
SRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRL
LEELGAITTYKLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSA
LSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFVNLWNYLGEQQKALSS
NAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHI
ALLTGLLSHIGMKDADKQEYTGARNARFSIFPGSGLFKKPPKWVMVAELV
ETSRLWGRIAARIDPEWVEPVAQHLIKRTYSEPHWERAQGAVMATEKVTV
YGLPIVAARKVNYSQIDPALCRELFIRHALV

Ligand information

>6zww Chain F (length=10)

uuuuuuuuuu

..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zww Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.
• Resolution: 3.16 Å
• Binding residue (original residue number in PDB): R131 R132 R159 T174 G176 A180 E300 R301 A325 R326 T348 N349 V350 S354 R370 Q439 Q495 P497 V498 Q528 R533 Q600 Q642 F655 F661 R682
• Binding residue (residue number reindexed from 1): R117 R118 R145 T160 G162 A166 E282 R283 A307 R308 T330 N331 V332 S336 R352 Q421 Q471 P473 V474 Q504 R509 Q576 Q618 F631 F637 R658

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003724 RNA helicase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

External links

• PDB: RCSB:6zww, PDBe:6zww, PDBj:6zww
• PDBsum: 6zww
• PubMed: 34290142
• UniProt: P43329|HRPA_ECOLI ATP-dependent RNA helicase HrpA (Gene Name=hrpA)