Structure of PDB 6zn2 Chain E Binding Site BS01

Receptor Information
>6zn2 Chain E (length=335) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQ
YRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFS
GYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQ
YIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASLGASDEE
IEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAF
DPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPY
TLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6zn2 Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		A296 E364 S367 Y370 W371 Y422
Binding residue
(residue number reindexed from 1)		A134 E202 S205 Y208 W209 Y260
Enzymatic activity
Enzyme Commision number 1.14.16.2: tyrosine 3-monooxygenase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0009072 aromatic amino acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6zn2, PDBe:6zn2, PDBj:6zn2
PDBsum6zn2
PubMed35013193
UniProtP07101|TY3H_HUMAN Tyrosine 3-monooxygenase (Gene Name=TH)

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