Structure of PDB 6wrs Chain E Binding Site BS01

Receptor Information
>6wrs Chain E (length=111) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEAKAVARTIRIAPRKVRLVLDLIRGKNAAEAIAILKLTNKASSPVIEKV
LMSALANAEHNYDMNTDELVVKEAYANEGPTLKRFRPRAQGRASAINKRT
SHITIVVSDAK
Ligand information
>6wrs Chain 1 (length=2698) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acgagcgaauucagacaaacuccgaaugccaauuaauuuaacuugggagu
cagaacaugggugauaagguccguguucgaaagggaaacagcccagacca
ccagcuaaggucccaaaauauauguuaaguggaaaaggauguggcguugc
cacagagugacacugcgccgaaaauguaccggggcuaaacauauuaccga
agcuguggauuguccuuuggacaaugguaggagagcguucuaagggcguu
gaagcaugaucguaaggacauguggagcgcuuagaagugagaaugccggu
gugaguagcgaaagacgggugagaaucccguccaccgauugacuaagguu
uccagaggaaggcucguccgcucuggguuagucggguccuaagcugaggc
cgacaggcguaggcgauggauaacagguugauauuccuguaccaccuaua
aucguaucgauggggggacgcaguaggauaggcgaagcgugcgauuggau
ugcacgucuaagcaguaaggcuguccgguagcugagcugugauggggaga
agaccuucgagucguugauuucacacugccgagaaaagccucuagauaga
aaauaggugcccguaccgcaaaccgacacagguagucaagaugagaauuc
uaaggugagcgagcgaacucucguuaaggaacucggcaaaaugaccccgu
aacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccgca
gugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaaac
cguaaggugauguauaggggcugacgccugcccagugcuggaagguuaag
aggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacggc
ggccguaacuauaacgguccuaagguagcgaaauuccuugucggguaagu
uccgacccgcacgaaaggcguaacgauuugggcacugucucaacgagaga
cucggugaaaucauaguaccugugaagaugcagguuacccgcgacaggac
ggaaagaccccguggagcuuuacuguagccugauauugaaauucggcuuu
cuaacccgcaccacuuaucguggugggagacagugucaggcgggcaguuu
gacuggggcggucgccuccuaaaagguaacggaggcgcucaaagguuccc
ucagaaugguuggaaaucauucauagaguguaaaggcauaagggagcuug
acugcgagaccuacaagucgagcagggucgaaagacggacuuagugaucc
ggugguuccgcauggaagggccaucgcucaacggauaaaagcuaccccgg
ggauaacaggcuuaucucccccaagaguucacaucgacggggagguuugg
caccucgaugucggcucaucgcauccuggggcuguagucggucccaaggg
uugggcuguucgcccauuaaagcgguacgcgagcuggguucagaacgucg
ugagacaguucggucccuauccgucgugggcguaggaaauuugagaggag
cuguccuuaguacgagaggaccgggauggacauaccucugguguaccagu
ugucgugccaacggcauagcuggguagcuauguguggacgggauaagugc
ugaaagcaucuaagcaugaagccccccucaagaugagauuucccaacuuc
gguuauaagaucccucaaagaugaugagguuaauagguucgagguggaag
cauggugacauguggagcugacgaauacuaaucgaucgaagacuuaau
<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<......
<<<<<<.((..((.>>>.....<<<<<<<..<<.))..))..>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<...........>>>>>>.>>.>>....<<<<<......<<....>
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<<<.<...
........<..<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>...>.....>.>>>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>.............}....>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<........>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>
..<<<<<<<<<<......>>>>>>>>>>....<<<......>>>...<<<
<.<<<...<<<(((.....<<<<<<...........<<..<<<<.<<<<.
.......>>>>.>>>>.>>...........))).....>>>>>>.>>>..
.>>>>>>><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<...
...<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>>
<......<.....<<<<<<.......>>>>>><<<<....<<<<<.<<..
.<<<<<<...<<.....>>.>>>>>>....((<<<<.<<.<.<<<...<<
<....>>>...>>>..>>>...<<<<<........>>>>>))<<<<<<<.
......<<...<<<<....<<<<...<<...<....<.<...........
..>.>.<<...<<<<...<<<.........>>>...>>>>....>>....
.<....>........>....>>...>>>>.........>>>>..>>....
..>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......>>
>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<..
...<..>......>>>>><<<<<<<.<<<<....>>>>.>>>>>>>....
........<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<
<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<..<
<...<<<<<..<<....>>...>>>>>...>>..>>>>>>>>>..>>>>>
<<<<<<.......>>>>>>........<...........<<<<<......
.>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.
>>>>.>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.
[[......<<<<.[[<<<<..<<<<..<<<<<<<<<.<<<<.<..>.>>>
>....<<.<<<<<.......>>>>>>>.....>>>>>>>>>...>>>>..
<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<<<<<
...<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>..
.<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))]......<
<<<<<<.((..>>>>..))>>>>>>>.............>>>>..]]>>>
>.......<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>
>.>.......<<<<<.<.<<<<..<<<<<<<<<......>>>>>>..>>>
.<<<<<.....>>>>>.....>>>>...>...>>>.>>....<<<<<<<.
...>>>.>>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..
<<<<<<<...............>>>>>>>.<<<<<...<<<<...<<<<<
<<<<<......>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<
<...........>>>>>...>>>>.>>>>.......>>>>>>>.<<<...
.>>>....<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<
<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6wrs Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R8 R11 R15 K16 R18 K41 A42 K49 S53 A56 N57 H60 N61 P80 R84 R86 P87 R88 A89 Q90 R92 S94 N97
Binding residue
(residue number reindexed from 1)		R8 R11 R15 K16 R18 K41 A42 K49 S53 A56 N57 H60 N61 P80 R84 R86 P87 R88 A89 Q90 R92 S94 N97
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6wrs, PDBe:6wrs, PDBj:6wrs
PDBsum6wrs
PubMed32566908
UniProtQ2FW11|RL22_STAA8 Large ribosomal subunit protein uL22 (Gene Name=rplV)

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