Structure of PDB 6usj Chain E Binding Site BS01

Receptor Information
>6usj Chain E (length=99) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQ
SSAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGER
Ligand information
>6usj Chain I (length=160) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccacaaggcctggatgtatatatctgacacgtgcctggagactagggagt
aatccccttggcggttaaaacgcgggggacagcgcgtacgtgcgtttaag
cggtgctagagctgtctacgaccaattgagcggcctcggcaccggattct
caggcctggc
Receptor-Ligand Complex Structure
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PDB6usj Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1.
Resolution10.5 Å
Binding residue
(original residue number in PDB)		R40 Y41 R42 G44 T45 V46 A47 R63 K64 L65 R69 R83
Binding residue
(residue number reindexed from 1)		R5 Y6 R7 G9 T10 V11 A12 R28 K29 L30 R34 R48
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0045296 cadherin binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0010467 gene expression
GO:0032200 telomere organization
GO:0040029 epigenetic regulation of gene expression
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6usj, PDBe:6usj, PDBj:6usj
PDBsum6usj
PubMed33141820
UniProtP68431|H31_HUMAN Histone H3.1 (Gene Name=H3C1)

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