Structure of PDB 6uq2 Chain E Binding Site BS01

Receptor Information
>6uq2 Chain E (length=212) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRP
QRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEK
NFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKH
IRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSE
TSGRYASYRICM
Ligand information
Receptor-Ligand Complex Structure
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PDB6uq2 RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-pi and CH-pi interactions.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		V90 S119
Binding residue
(residue number reindexed from 1)		V87 S116
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0001055 RNA polymerase II activity
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0006361 transcription initiation at RNA polymerase I promoter
GO:0006362 transcription elongation by RNA polymerase I
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006368 transcription elongation by RNA polymerase II
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005666 RNA polymerase III complex
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6uq2, PDBe:6uq2, PDBj:6uq2
PDBsum6uq2
PubMed32284409
UniProtP20434|RPAB1_YEAST DNA-directed RNA polymerases I, II, and III subunit RPABC1 (Gene Name=RPB5)

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