Structure of PDB 6ud4 Chain E Binding Site BS01

Receptor Information
>6ud4 Chain E (length=132) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFTFAAFCYMLSLVLCAALIFFAIWHIIAFDELRTDARERLRNIERICFL
LRKLVLPEYSIHSLFCIMFLCAQEWLTLGLNVPLLFYHFWRYFHCPADTL
SYCQKEAWCKLAFYLLSFFYYLYCMIYTLVSS
Ligand information
Ligand IDCLR
InChIInChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKeyHVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
FormulaC27 H46 O
NameCHOLESTEROL
ChEMBLCHEMBL112570
DrugBankDB04540
ZINCZINC000003875383
PDB chain6ud4 Chain A Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ud4 Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		M11 M153
Binding residue
(residue number reindexed from 1)		M10 M125
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016247 channel regulator activity
Biological Process
GO:0016192 vesicle-mediated transport
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0051668 localization within membrane
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
GO:2000311 regulation of AMPA receptor activity
Cellular Component
GO:0005886 plasma membrane
GO:0032281 AMPA glutamate receptor complex
GO:0043198 dendritic shaft
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ud4, PDBe:6ud4, PDBj:6ud4
PDBsum6ud4
PubMed31806817
UniProtQ6ZWS4|CNIH3_MOUSE Protein cornichon homolog 3 (Gene Name=Cnih3)

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