Structure of PDB 6tvt Chain E Binding Site BS01

Receptor Information
>6tvt Chain E (length=313) Species: 1572188 (Influenza A virus (A/harbour seal/Germany/1/2014(H10N7))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPDKICLGHHAVANGTIVKTLTNEQEEVTNATETVESTSLNRLCMKGRNH
KDLGNCHPIGMLIGTPACDLHLTGTWDTLIERKNAIAYCYPGATVNEEAL
RQKIMESGGISKINTGFTYGSSINSAGTTKACMRNGGNSFYAELKWLVSK
NKGQNFPQTTNTYRNADTAEHLIMWGIHHPSSTQEKNDLYGTQSLSISVG
SSTYKNNFVPVVGGLSRIDFHWTLVQPGDKITFSHNGGLIAPSRVSKLIG
RGLGIQSEAPIDNSCESKCFWRGGSINTRLPFQNLSPRTVGQCPKYVNKK
SLMLATGMRNVPE
Ligand information
Ligand IDSIA
InChIInChI=1S/C11H19NO9/c1-4(14)12-7-5(15)2-11(20,10(18)19)21-9(7)8(17)6(16)3-13/h5-9,13,15-17,20H,2-3H2,1H3,(H,12,14)(H,18,19)/t5-,6+,7+,8+,9+,11+/m0/s1
InChIKeySQVRNKJHWKZAKO-YRMXFSIDSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CC(=O)N[CH]1[CH](O)C[C](O)(O[CH]1[CH](O)[CH](O)CO)C(O)=O
OpenEye OEToolkits 1.5.0CC(=O)NC1C(CC(OC1C(C(CO)O)O)(C(=O)O)O)O
OpenEye OEToolkits 1.5.0CC(=O)N[C@@H]1[C@H](C[C@@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)O)O)O
ACDLabs 10.04O=C(O)C1(O)OC(C(O)C(O)CO)C(NC(=O)C)C(O)C1
CACTVS 3.341CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(O[C@H]1[C@H](O)[C@H](O)CO)C(O)=O
FormulaC11 H19 N O9
NameN-acetyl-alpha-neuraminic acid;
N-acetylneuraminic acid;
sialic acid;
alpha-sialic acid;
O-SIALIC ACID
ChEMBLCHEMBL1234621
DrugBankDB03721
ZINCZINC000004081651
PDB chain6tvt Chain K Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6tvt Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Y88 T126 T127 K128 W144 E183 S220
Binding residue
(residue number reindexed from 1)		Y90 T128 T129 K130 W146 E185 S216
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane
Cellular Component
GO:0019031 viral envelope

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6tvt, PDBe:6tvt, PDBj:6tvt
PDBsum6tvt
PubMed33031770
UniProtA0A0A7HR51

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