Structure of PDB 6s6z Chain E Binding Site BS01

Receptor Information
>6s6z Chain E (length=1083) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PYEWENPQLVSEGTEKSHASFIPYLDPFSGEWEYPEEFISLNGNWRFLFA
KNPFEVPEDFFSEKFDDSNWDEIEVPSNWEMKGYGKPIYTNVVYPFEPNP
PFVPKDDNPTGVYRRWIEIPEDWFKKEIFLHFEGVRSFFYLWVNGKKIGF
SKDSCTPAEFRLTDVLRPGKNLITVEVLKWSDGSYLEDQDMWWFAGIYRD
VYLYALPKFHIRDVFVRTDLDENYRNGKIFLDVEMRNLGEEEEKDLEVTL
ITPDGDEKTLVKETVKPEDRVLSFAFDVKDPKKWSAETPHLYVLKLKLGE
DEKKVNFGFRKIEIKDGTLLFNGKPLYIKGVNRHEFDPDRGHAVTVERMI
QDIKLMKQHNINTVRTSHYPNQTKWYDLCDYFGLYVIDEANIESHGIDWD
PEVTLANRWEWEKAHFDRIKRMVERDKNHPSIIFWSLGNEAGDGVNFEKA
ALWIKKRDNTRLIHYEGTTRRGESYYVDVFSLMYPKMDILLEYASKKREK
PFIMCEYAHAMGNSVGNLKDYWDVIEKYPYLHGGCIWDWVDQGIRKKDEN
GREFWAYGGDFGDTPNDGNFCINGVVLPDRTPEPELYEVKKVYQNVKIRQ
VSKDTYEVENRYLFTNLEMFDGAWKIRKDGEVIEEKTFKIFAEPGEKRLL
KIPLPEMDDSEYFLEISFSLSEDTPWAEKGHVVAWEQFLLKAPAFEKKSI
SDGVSLREDGKHLTVEAKDTVYVFSKLTGLLEQILHRRKKILKSPVVPNF
WRVPTDNDIGNRMPQRLAIWKRASKERKLFKMHWKKEENRVSVHSVFQLP
GNSWVYTTYTVFGNGDVLVDLSLIPAEDVPEIPRIGFQFTVPEEFGTVEW
YGRGPHETYWDRKESGLFARYRKAVGEMMHRYVRPQETGNRSDVRWFALS
DGETKLFVSGMPQIDFSVWPFSMEDLERVQHISELPERDFVTVNVDFRQM
GLGGDDSWGAMPHLEYRLLPKPYRFSFRMRISEEIPSWRVLAAIPETLHV
EMSSEDVIREGDTLRVKFSLLNDTPLSKEKQVVLFVDGNEYSVRRVVIPP
FKKEELVFKVEGLKKGEHLIHTNLNTRKTIYVR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6s6z Chain E Residue 3001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6s6z The cryo-EM Structure ofThermotoga maritimabeta-Galactosidase: Quaternary Structure Guides Protein Engineering.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		A511 G513 G575 E584 E586
Binding residue
(residue number reindexed from 1)		A510 G512 G574 E583 E585
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.23: beta-galactosidase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004565 beta-galactosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0005990 lactose catabolic process
GO:0009056 catabolic process
Cellular Component
GO:0009341 beta-galactosidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6s6z, PDBe:6s6z, PDBj:6s6z
PDBsum6s6z
PubMed31874027
UniProtQ56307|BGAL_THEMA Beta-galactosidase (Gene Name=lacZ)

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