Structure of PDB 6r6h Chain E Binding Site BS01

Receptor Information
>6r6h Chain E (length=310) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGG
NLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIEN
AKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPT
RTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYA
LEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKL
EQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVI
KDKLFNQINI
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6r6h Chain E Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6r6h Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Resolution8.4 Å
Binding residue
(original residue number in PDB)		R106 I150 D151 T154
Binding residue
(residue number reindexed from 1)		R83 I127 D128 T131
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.-.-
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0019784 deNEDDylase activity
GO:0019899 enzyme binding
GO:0035718 macrophage migration inhibitory factor binding
GO:0046872 metal ion binding
GO:0140492 metal-dependent deubiquitinase activity
Biological Process
GO:0000338 protein deneddylation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006508 proteolysis
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0045116 protein neddylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046328 regulation of JNK cascade
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051726 regulation of cell cycle
GO:1903894 regulation of IRE1-mediated unfolded protein response
GO:1990182 exosomal secretion
GO:2000434 regulation of protein neddylation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0008021 synaptic vesicle
GO:0008180 COP9 signalosome
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6r6h, PDBe:6r6h, PDBj:6r6h
PDBsum6r6h
PubMed31444342
UniProtQ92905|CSN5_HUMAN COP9 signalosome complex subunit 5 (Gene Name=COPS5)

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