Structure of PDB 6qkl Chain E Binding Site BS01

Receptor Information

>6qkl Chain E (length=128) Species: 44689 (Dictyostelium discoideum)

SNYRVSLGLPVGAVMNSADNSGAKNLYVIAVKGIKGRLNRLPSAGVGDMV
MATVKKGKPELRKKVCTGLVVRQRKHWKRKDGVYIYFEDNAGVMCNPKGE
VKGNILGPVAKECSDLWPKVATNAGTIV

Ligand information

>6qkl Chain N (length=1158)

auuagcaguuucgggggcguaaugcucucagcugauucucaaacucugaa
cauuuuugguaagcagaacuggcgauguggguugaaccaaauauugggau
aagacgucuaacauucacuaauagauaccacaaaagguguuaguucauua
agacagcaggacgguggccauggaagucgguauccgcuaaggagugugua
acaacucaccugccaaauggacuagcccugaaaauggaugacgcuagcag
uggauggucgaugcccaaucguuaaaagaagugauaauacuuuuaacaau
ccaacuguuuaauuaaaacaaagcauugcgauaagcuuaaaagcuuuuga
cgcaaugugauuucugcccagugcucugaaugucaaagugaagagauuca
accuagcacggguaaacggcgggaguaacuaugacucucuuaagguagcc
aaaugccucgucaucuaauuagugacgcgcaugaauggaucaaugagauu
cccacugucccuaacuacuauacagcgaaaccacugcaaggggaacgggc
cuugcaaaaacagcggggaaagaagacccuguugagcuugacucuagucu
gauauuacaguuucagguggggaguuuggcuggggcggcacauuuguuaa
aagauaacgcaaguguccaaaggcaggcucagugagaacagaaaucucac
guagaguaaaagggcaaaagccugcuugauucugauuuucaguacuaauc
ggaacugggaaaccagggccuaucgauccuuuaugugcuuaaaucuuaac
ccuagaggugucagaaaaguuaccacagggauaacuggcuuguggcagcc
aagcgcucauagcgacgcugcuuuuugauccuucgaugucggcucuucuu
aucauugugaagcagaauucacaaaguguuggauuguucacccacuaaca
aggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccu
acuguugucaguuugcguaauaguagcaugauuuaguacgagaggaacug
ucaugccggaucacuggucuguagguuuauuugacaaaauagugaccugc
cgcuaccauccguuggauaauggcugaacgccucuaagucagaauccauu
cuagaaac

.....<<<<...<<<<<<.....>>>>>>.>>>>................
<<.<<<<<.....>>>>>.>>......<<<......>>>...<<<<<<..
..<<<(((...<<<<<<<....<<..........<<<.<<<<<<<<<<..
.....<<<<<.<<...<<<.........>>>...>>.........<<...
...>>...>>>>>...>>>>>>>>>>>>>..........))).>>....>
>>>>>>>>>....>>>>>>.<<<<<<<<...........>>>>>>>><<<
<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>.....
.>>>>>>>...<<..<<<..<<<<<.....<<<....<<<<<....>>>>
.>...>>>..>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<.......>>>>>.....>.....>>....>>.>>>>
....................................<<<<<........>
>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<
<<.<<....>>.>>>>>>..>>>>>...<<<.....>>>..<<<<<<...
........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>
.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>
>>>>.<<<....>>>.>>))).......<<<<<...<.<<.......>>.
>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<.
..<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<
..<<<<<<<<<......>>>>>>..>>>.<<<.<.....>.>>>.....>
>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>
.>>>>>..........<<..<<<..<<<<<<<.................>
>>>>>><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>..
.>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>..
>>>...>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qkl Mechanism of eIF6 release from the nascent 60S ribosomal subunit.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): Y11 R12 S14 I37 K40 G41 I42 K43 G44 R45 L46 N47 R48 L49 M59 T61 R70 K71 V73 K83 H84 K86 Y92
• Binding residue (residue number reindexed from 1): Y3 R4 S6 I29 K32 G33 I34 K35 G36 R37 L38 N39 R40 L41 M51 T53 R62 K63 V65 K75 H76 K78 Y84

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0070180 large ribosomal subunit rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0031012 extracellular matrix
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6qkl, PDBe:6qkl, PDBj:6qkl
• PDBsum: 6qkl
• PubMed: 26479198
• UniProt: Q54G86|RL23_DICDI Large ribosomal subunit protein uL14 (Gene Name=rpl23)