Structure of PDB 6q2j Chain E Binding Site BS01

Receptor Information
>6q2j Chain E (length=571) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNHGFPLLTVYLKVFLS
PGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPG
TFHQFRLLPVQFLCPNISVAYRLLGLPFRCAPDSLEVSTRWALDREQREK
YELVAVCTVHEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDT
VVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQ
ANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSGVLLLHFNVSVL
PVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSCST
LGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLL
VTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGI
TRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRG
IKAGYGTCNCFPEEEKCFCEP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6q2j Chain E Residue 708 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6q2j Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		D266 S268 D300 D302 D378
Binding residue
(residue number reindexed from 1)		D225 S227 D259 D261 D337
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6q2j, PDBe:6q2j, PDBj:6q2j
PDBsum6q2j
PubMed31535977
UniProtP07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)

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