Structure of PDB 6neq Chain E Binding Site BS01

Receptor Information
>6neq Chain E (length=309) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRKDLNRGQIIGEGRRGFLWPGLNAPLMKSGAIQTITQRSKEEQEKVEAD
MVQQREEWDRKRKMKVKRERGWSGNSWGGISLGPPDPGPNGETYDDFDTR
ILEVRNVFNMTAKEGRKRSVRVLVAVGNGRGAAGFAIGKATERADAFRKA
KNRAVHYLHYIERYEDHTIYHDISLTFKRTHIKMKKQPRGYGLRCHRAIT
TICRLIGIKDMYAKVSGSVNMLSLTRGLFQGLSRQETHQQLADKKSLHVV
EFREECGPLPIVVASPQGALRKDPEPEDEVPDIKLDWDDVKAVQGMKRSV
WSGLKRAAT
Ligand information
>6neq Chain A (length=952) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agguuuggucccagccuuccuguuaacucuuaauaaacuuacacaugcaa
gcaucuacaccccagugagaaugcccucuagguuauuaaaacuaagagga
gcuggcaucaagcacacacccuguagcucacgacgccuugcuuaaccaca
ccccacgggaaacagcagugacaaaaauuaagccauaaacgaaaguuuga
cuaaguuauauuaauuaggguugguaaaucucgugccagccaccgcgguc
auacgauuaacccaagcuaacaggaguacggcguaaaacguguuaaagca
ccauaccaaauaggguuaaauucuaacuaagcuguaaaaagccaugauua
aaauaaaaauaaaugacgaaagugacccuacaauagccgacgcacuauag
cuaagacccaaacugggauuagauaccccacuaugcuuagcccuaaacac
agauaauuacauaaacaaaauuauucgccagaguacuacuagcaacagcu
uaaaacucaaaggacuuggcggugcuuuauauccuucuagaggagccugu
ucuauaaucgauaaaccccgauaaaccucaccaauucuugcuaauacagu
cuauauaccgccaucuucagcaaacccuaaaaaggaaaaaaaguaagcgu
aauuaugauacauaaaaacguuaggucaagguguaaccuaugaaauggga
agaaaugggcuacauucucuacaccaagagaaucaagcacgaaaguuauu
augaaaccaauaaccaaaggaggauuuagcaguaaacuaagaauagagug
cuuaguugaauuaggccaugaagcacgcacacaccgcccgucacccuccu
caaauagauucagugcaucuaacccuauuuaaacgcacuagcuacaugag
aggagacaagucguaacaagguaagcauacuggaaagugugcuuggauaa
au
.<<.<<.{..[[>>.>>.<<<<<<<.<..<<<<<<<<..<.<<<.<<<..
<......>......<<......<<<<<<<.<<<<.....>>>>.>>>>>.
>>.<<<....<<...<<<...>>>..>>......>>>..<.....>.>>.
<<.....>>.....>>>>>>>.........<<....<<<<....>>>>..
>>...>>.>>>>>>...<<<<<<<<.....(((.....((.>>>))....
...)))..>>>>>..>.>>>>>>>.....<<<((.....<<<<....<..
..........<<<<<<.......<<<.<<.<<<......>>>..>>.>>>
...............<<....>>.>>>>>>......>....>>>>....<
<<<<<...<<...<<<<.........>>>>...>>>>>>>>.........
.<<<<<<.......))...>>>>>>.>>>.<<<.......<<<....>>>
.....>>>...]]..}<<<<<.<<<<<<<...<<..<<<<<..<<<<<<<
<.<.....<<........>>..........<<<.<<<...........<<
.<<<...<<<<<<......<<....<<<....>>>...........>>..
..<<<<.....>>>>......>.>>>...>>.>>>>>....>>>.>>>..
>..>>>>>>>>.....<<<<......>>>>..............<<<<<<
........>>>>>>..........>>>>>.....<<<<<<<.........
>>>>>>>......>>...>>>>>>>>>>.>>.......<<.<...<<<<<
<...<<.....<<<<<....<<......>>....>>>>>...>>.....>
>>>>>....>.>>.........<<<<<<<<<....>>>>>>>>>......
..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6neq Structure of Human Mitochondrial Translation Initiation Factor 3 Bound to the Small Ribosomal Subunit.
Resolution3.32 Å
Binding residue
(original residue number in PDB)
S194 G195 R226 V228 F229 N230 M231 A233 K234 R237 R242 I258 K260 D266 R269 K270 R274 Y278 T297 F298 K299 R300 H317 R318 K335 V340 R347 K405 W408 R419 S420 V421 W422 R427
Binding residue
(residue number reindexed from 1)
S73 G74 R105 V107 F108 N109 M110 A112 K113 R116 R121 I137 K139 D145 R148 K149 R153 Y157 T176 F177 K178 R179 H196 R197 K214 V219 R226 K284 W287 R298 S299 V300 W301 R306
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6neq, PDBe:6neq, PDBj:6neq
PDBsum6neq
PubMed30677741
UniProtQ2KID9|RT05_BOVIN Small ribosomal subunit protein uS5m (Gene Name=MRPS5)

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