Structure of PDB 6la8 Chain E Binding Site BS01

Receptor Information
>6la8 Chain E (length=99) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQS
SAVMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Ligand information
>6la8 Chain I (length=349) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgctggaaaaaaaaaacgcatcccggtgccgaggccgctcaattggtcgt
agacagctctagcaccgcttaaacgcacgtacgcgctgtctaccgcgttt
taaccgccactagaagcgcttactagtctccaggcacgtgtgagaccggc
acatgaaaaaaaaaagcatgctcgagtatgaaaaaaaaaacgcatcccgg
tgccgaggccgctcaattggtcgtagacagctctagcaccgcttaaacgc
acgtacgcgctgtctaccgcgttttaaccgccactagaagcgcttactag
tctccaggcacgtgtgagaccggcacatgaaaaaaaaaaccagcggtac
Receptor-Ligand Complex Structure
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PDB6la8 Near-atomic resolution structures of interdigitated nucleosome fibres.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		H39 R40 Y41 P43 G44 V46 R49 R63 K64 L65 R69 R83
Binding residue
(residue number reindexed from 1)		H3 R4 Y5 P7 G8 V10 R13 R27 K28 L29 R33 R47
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0045296 cadherin binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0010467 gene expression
GO:0032200 telomere organization
GO:0040029 epigenetic regulation of gene expression
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6la8, PDBe:6la8, PDBj:6la8
PDBsum6la8
PubMed32958761
UniProtP68431|H31_HUMAN Histone H3.1 (Gene Name=H3C1)

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