Structure of PDB 6l9l Chain E Binding Site BS01
Receptor Information
>6l9l Chain E (length=175) Species:
9606
(Homo sapiens) [
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GPHSMRYYETATSRRGLGEPRYTSVGYVDDKEFVRFDSDAENPRYEPQVP
WMEQEGPEYWERITQIAKGQEQWFRVNLRTLLGYYNQSAGGTHTLQRMYG
CDVGSDGRLLRGYEQFAYDGCDYIALNEDLRTWTAADMAAQITRRKWEQA
GAAEYYRAYLEGECVEWLHRYLKNG
Ligand information
>6l9l Chain F (length=9) Species:
9606
(Homo sapiens) [
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SPSYAYHQF
Receptor-Ligand Complex Structure
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PDB
6l9l
Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cells in cancer.
Resolution
2.399 Å
Binding residue
(original residue number in PDB)
Y7 Y45 R62 I63 G69 Q70 W73 N77 L81 Y84 R97 Y99 T143 K146 W147 A152 Y155 Y156 Y159 W167 Y171
Binding residue
(residue number reindexed from 1)
Y7 Y45 R62 I63 G69 Q70 W73 N77 L81 Y84 R97 Y99 T143 K146 W147 A152 Y155 Y156 Y159 W167 Y171
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6l9l
,
PDBe:6l9l
,
PDBj:6l9l
PDBsum
6l9l
PubMed
34074778
UniProt
P01897
|HA1L_MOUSE H-2 class I histocompatibility antigen, L-D alpha chain (Gene Name=H2-L)
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