Structure of PDB 6l4a Chain E Binding Site BS01

Receptor Information
>6l4a Chain E (length=97) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSA
VMALQEACEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA
Ligand information
>6l4a Chain I (length=485) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattactccctagtctccaggcacgtgtcagatatatacatcgattggat
aggcccggacggcctggataatcagaatcccggtgccgaggccgctcaat
tggtcgtagacagctctagcaccgcttaaacgcacgtacgcgctgtcccc
cgcgttttaaccgccaaggggattactccctagtctccaggcacgtgtca
gatatatacatcgattggataggccccaacggcctggataatcagaatcc
cggtgccgaggccgctcaattggtcgtagacagctctagcaccgcttaaa
cgcacgtacgcgctgtcccccgcgttttaaccgccaaggggattactccc
tagtctccaggcacgtgtcagatatatacatcgat
Receptor-Ligand Complex Structure
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PDB6l4a Cryo-EM Structures of Centromeric Tri-nucleosomes Containing a Central CENP-A Nucleosome.
Resolution12.3 Å
Binding residue
(original residue number in PDB)		R40 Y41 R42 P43 G44 V46 R49 R63 L65 R69 D81 R83
Binding residue
(residue number reindexed from 1)		R2 Y3 R4 P5 G6 V8 R11 R25 L27 R31 D43 R45
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0045296 cadherin binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0010467 gene expression
GO:0032200 telomere organization
GO:0040029 epigenetic regulation of gene expression
Cellular Component
GO:0000786 nucleosome
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6l4a, PDBe:6l4a, PDBj:6l4a
PDBsum6l4a
PubMed31711756
UniProtP68431|H31_HUMAN Histone H3.1 (Gene Name=H3C1)

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