Structure of PDB 6kc4 Chain E Binding Site BS01
Receptor Information
>6kc4 Chain E (length=101) Species:
9606
(Homo sapiens) [
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SKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQ
RRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIP
K
Ligand information
>6kc4 Chain F (length=6) Species:
32630
(synthetic construct) [
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DEYENV
Receptor-Ligand Complex Structure
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PDB
6kc4
High-resolution structural analysis shows how different crystallographic environments can induce alternative modes of binding of a phosphotyrosine peptide to the SH2 domain of Fer tyrosine kinase.
Resolution
1.37 Å
Binding residue
(original residue number in PDB)
R467 R483 S485 H486 G487 V493 R503 H504 F505 I506
Binding residue
(residue number reindexed from 1)
R16 R32 S34 H35 G36 V42 R52 H53 F54 I55
Enzymatic activity
Enzyme Commision number
2.7.10.2
: non-specific protein-tyrosine kinase.
External links
PDB
RCSB:6kc4
,
PDBe:6kc4
,
PDBj:6kc4
PDBsum
6kc4
PubMed
31441171
UniProt
P16591
|FER_HUMAN Tyrosine-protein kinase Fer (Gene Name=FER)
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