Structure of PDB 6je4 Chain E Binding Site BS01

Receptor Information
>6je4 Chain E (length=1056) Species: 604162 (Neisseria meningitidis 8013) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAFKPNSINYILGLAIGIASVGWAMVEIDEEENPIRLIDLGVRVFERAEV
PKTGDSLAMARRLARSVRRLTRRRAHRLLRTRRLLKREGVLQAANFDENG
LIKSLPNTPWQLRAAALDRKLTPLEWSAVLLHLIKHRGYLSQRKNELGAL
LKGVAGNAHALQTGDFRTPAELALNKFEKESGHIRNQRSDYSHTFSRKDL
QAELILLFEKQKEFGNPHVSGGLKEGIETLLMTQRPALSGDAVQKMLGHC
TFEPAEPKAAKNTYTAERFIWLTKLNNLRILEQGSERPLTDTERATLMDE
PYRKSKLTYAQARKLLGLEDTAFFKGLRYGKDNAEASTLMEMKAYHAISR
ALEKEGLKDKKSPLNLSPELQDEIGTAFSLFKTDEDITGRLKDRIQPEIL
EALLKHISFDKFVQISLKALRRIVPLMEQGKRYDEACAEIYGDNTEEKIY
LPPIPADEIRNPVVLRALSQARKVINGVVRRYGSPARIHIETAREVGKSF
KDRKEIEKRQEENRKDREKAAAKFREYFPNFVGEPKSKDILKLRLYEQQH
GKCLYSGKEINLGRLNEKGYVEIDAALPFSRTWDDSFNNKVLVLGSENQN
KGNQTPYEYFNGKDNSREWQEFKARVETSRFPRSKKQRILLQKFDEDGFK
ERNLNDTRYVNRFLCQFVADRMRLTGKGKKRVFASNGQITNLLRGFWGLR
KVRAENDRHHALDAVVVACSTVAMQQKITRFVRYKEMNALHQKTHFPQPW
EFFAQEVMIRVFGKPDGKPEFEEADTLEKLRTLLAEKLSSRPEAVHEYVT
PLFVSRAPNRKMSGQGHMETVKSAKRLDEGVSVLRVPLTQLKLKDLEKMV
NREREPKLYEALKARLEAHKDDPAKAFAEPFYKYDKAGNRTQQVKAVRVE
QVQKTGVWVRNHNGIADNATMVRVDVFEKGDKYYLVPIYSWQVAKGILPD
RAVVQGKDEEDWQLIDDSFNFKFSLHPNDLVEVITKKARMFGYFASCHRG
TGNINIRIHDLDHKIGKNGILEGIGVKTALSFQKYQIDELGKEIRPCRLK
KRPPVR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6je4 Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States.
Resolution3.069 Å
Binding residue
(original residue number in PDB)		Y140 R144 K145 G156 L158 L159 Y199 L246 M254 L255 K266 N285 R287 K333 K390 D418 K419 F420 R440 D442 R473 K656 F657 D658 Y672 R675 E845 T846 Q981 N1029 G1049 G1051 K1053 T1054
Binding residue
(residue number reindexed from 1)		Y139 R143 K144 G148 L150 L151 Y191 L238 M246 L247 K258 N277 R279 K325 K382 D410 K411 F412 R432 D434 R460 K643 F644 D645 Y659 R662 E819 T820 Q955 N1003 G1023 G1025 K1027 T1028
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6je4, PDBe:6je4, PDBj:6je4
PDBsum6je4
PubMed31668930
UniProtC9X1G5|CAS9_NEIM8 CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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