Structure of PDB 6ivx Chain E Binding Site BS01

Receptor Information

>6ivx Chain E (length=226) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SLTEIEHLVQSVCKSYRETCQRLEDLLRQRSNIFSREEVTGYQRKSMWEM
WERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMC
RAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDE
IALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKL
PPAGKLASLCSQHVERLQIFQHLHPI

Ligand information

>6ivx Chain F (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

TNMGLEAIIRKALM

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6ivx Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold.
Resolution	2.35 Å
Binding residue (original residue number in PDB)	V332 K336 I350 L353 K354 S477 E481 Q484
Binding residue (residue number reindexed from 1)	V66 K70 I84 L87 K88 S211 E215 Q218

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:6ivx, PDBe:6ivx, PDBj:6ivx
PDBsum	6ivx
PubMed	30776227
UniProt	P51449\|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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