Structure of PDB 6hma Chain E Binding Site BS01

Receptor Information
>6hma Chain E (length=206) Species: 1280 (Staphylococcus aureus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANYDVLKLDGTKSGSIELSDAVFGIEPNNSVLFEAINLQRASLRQGTHAV
KNRSAVSGGGRKPWKQKGTGRARQGTIRAPQWRGGGIVFGPTPRSYAYKM
PKKMRRLALRSALSFKAQENGLTVVDAFNFEAPKTKEFKNVLSTLEQPKK
VLVVTENEDVNVELSARNIPGVQVTTAQGLNVLDITNADSLVITEAAAKK
VEEVLG
Ligand information
>6hma Chain A (length=2834) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uuaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgauga
aggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuuga
uccagagauuuccgaauggggaaacccagcaugaguuaugucauguuauc
gauaugugaauacauagcauaucagaaggcacacccggagaacugaaaca
ucuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggc
gagcgaaacgggaagagcccaaaccaacaagcuugcuuguugggguugua
ggacacucuacggaguuacaaaggacgacauuagacgaaucaucuggaaa
gaugaaucaaagaagguaauaauccuguagucgaaaauguugucucucuu
gaguggauccugaguacgacggagcacgugaaauuccgucggaaucuggg
aggaccaucuccuaaggcuaaauacucucuagugaccgauagugaaccag
uaccgugagggaaaggugaaaagcaccccggaaggggagugaaauagaac
cugaaaccgugugcuuacaaguagucagagcccguuaaugggugauggcg
ugccuuuuguagaaugaaccggcgaguuacgauuugaugcaagguuaagc
aguaaauguggagccguagcgaaagcgagucugaauagggcguuuaguau
uuggucguagacccgaaaccaggugaucuacccuuggucagguugaaguu
caggcugaauggaggaccgaaccgacuuacguugaaaagugagcggauga
acugaggguagcggagaaauuccaaucgaaccuggagauagcugguucuc
uccgaaauagcuuuagggcuagccucaagugaugauuauuggagguagag
cacuguuuggacgaggggccgguuaccgaauucagacaaacuccgaaugc
caauuaauuuaacuugggagucagaacaugggugauaagguccguguucg
aaagggaaacagcccagaccaccagcuaaggucccaaaauauauguuaag
uggaaaaggauguggcguugcccagacaacgucgagugacacugcgccga
aaauguaccggggcuaaacauauuaccgaagcuguggauuguccuuugga
caaugguaggagagcguucuaagggcguugaagcaugaucguaaggacau
guggagcgcuuagaagugagaaugccggugugaguagcgaaagacgggug
agaaucccguccaccgauugacuaagguuuccagaggaaggcucguccgc
ucuggguuagucggguccuaagcugaggccgacaggcguaggcgauggau
aacagguugauauuccuguaccaccuauaaucguuuuaaucgaugggggg
acgcaguaggauaggcgaagcgugcgauuggauugcacgucuaagcagua
aggcugaguauugguacucguuaaggcugagcugugauggggagaagaca
uugugucuucgagucguugauuucacacugccgagaaaagccucuagaua
gaaaauaggugcccguaccgcaaaccgacacagguagucaagaugagaau
ucuaaggugagcgagcgaacucucguuaaggaacucggcaaaaugacccc
guaacuucgggagaaggggugcucuuuaggguuaacgcccagaagagccg
cagugaauaggcccaagcgacuguuuaucaaaaacacaggucucugcuaa
accguaaggugauguauaggggcugacgccugcccggugcuggaagguua
agaggagugguuagcuucugcgaagcuacgaaucgaagccccaguaaacg
gcggccguauaacgguccuaagguagcgaaauuccuugucggguaaguuc
cgacccgcacgaaaggcguaacgauuugggcacugucucaacgagagacu
cggugaaaucauaguaccugugaagaugcagguuacccgcgacaggacgg
aaagaccccguggagcuuuacuguagccugauauugaaauucggcacgcu
uguacaggauagguaggagccuuugaaacgugagcgcuagcuuacgugga
ggcgcuggugggauacuacccagcuguguuggcuuucuaacccgcaccac
uuaucguggugggagacagugucaggcgggcaguuugacuggggcggucg
ccuccuaaaagguaacggaggcgcucaaagguucccucagaaugguugga
aaucauucauagaguguaaaggcauaagggagcuugacugcgagaccuac
aagucgagcagggucgaaagacggacuuagugauccggugguuccgcaug
gaagggccaucgcucaacggauaaaagcuaccccggggauaacaggcuua
ucucccccaagaguucacaucgacggggagguuuggcaccucgaugucgg
cucaucgcauccuggggcuguagucggucccaaggguugggcuguucgcc
cauuaaagcgguacgcgagcuggguucagaacgucgugagacaguucggu
cccuauccgucgugggcguaggaaauuugagaggagcuguccuuaguacg
agaggaccgggauggacauaccucugguguaccaguugucgugccaacgg
cauagcuggguagcuauguguggacgggauaagugcugaaagcaucuaag
caugaagccccccucaagaugagauuucccaacuucgguuauaagauccc
ucaaagaugaugagguuaauagguucgagguggaagcauggugacaugug
gagcugacgaauacuaaucgaucgaagacuuaau
<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<.....
.<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....
>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<
<<<<<<<.........>>>>>>>.>>.>>....<<<<<......<<....
>>.......>>>>.>.........<<....>>..<<<<<......<<...
..>>.....>>>>>..(((....<<<<<<<<<..>>>>>>>>>......<
<<<<<<<<...<<<<.......<<<<<<<<<<.<<<...<<<<<......
>>>>>((......<<<.....))>>>...>>>...>>>>>>>>>>>>>>.
>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>......<<<
<<..<<<<>>>>>..)))......]].>>>>>>>.]].............
..<<....>>....]].........<<<<....>>>>.............
}....>>>>>>>>>>>.......<<<<..<<<<......>>>>..>>>>.
..<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<<<...<<
<.....>>>...>>>...<<....>>..<<<<.....>>>>.....>>>>
>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<
<<<.>>>>>>.....>>>...<<<.<<<<<........>>>>>>>>....
>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..<<<
<<<....<<<<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<
...<<<<<<<<...<<.........>>...>>>>>>>>..>>.>.....>
>>>>.>>>>..>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>.
...<<<......>>>...<<<<.<<<...<<<(((.....<<<<<<....
.......<<..<<<<.<<<<........<..>....>>>>.>>>>.>>..
.........))).....>>>>>>.>>>...>>>>>>><<<<<<<...>>>
>>>>....>>>>>><.<<<<<<<.<<......<<<<<.<<....>>.>>>
>>...>>.>>>>>>>..>.....>>>>>><......<<....<<<<<<..
.....>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>
>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>..
.<<<<<........>>>>>))<<<<<<<..........<<<...<<<<..
..<<<<...<<...<....<.<<<.....{...>>>.>.<....<<<<..
.<<<.<<<<<<..>>>>>>......>>>...>>>>.....>.........
.................>....>>...>>>>.........>>>>..>>>.
....>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<.......
>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<<<<<
....<<..>>.....>>>>><<<<<<<.<..........>.>>>>>>>..
..........<<<<<<<<<..<<<.........>>>..<<<<<<<.....
<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<..
.<<...<<<<<<...........>>>>>>...>>...>>>>>>>>..>>>
>><<<<<.....>>>>>........<...........<<<<<<.....>>
>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>
>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[
......<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<<<<<<<<<.
..............<<..<<.........<<<<<<....>>>>>>.....
.>>............>>.....>.>>>>>>>>.>>>>....<<.<<<<<<
.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<<<....
..>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>
>..))>>>>>>>.............>>>>..]]>>>>.......<<<<.<
.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<
<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>
>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...
.]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......
........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>
>>..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>
>>>....>>>.>>>>.......>>>>>>>.<<<....>>>....<<<<<<
<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>.
..>>>..>>>>>.>>>...>>>>....>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hma Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus
Resolution2.65 Å
Binding residue
(original residue number in PDB)
Q40 R41 S43 R45 Q46 T48 N53 R54 S55 S58 R62 K63 Q67 K68 G69 G71 R72 R74 G76 Q82 W83 R84 I88 V89 F90 R95 K100 K103 K104 R106 T136 K151 L165 R168 N169
Binding residue
(residue number reindexed from 1)
Q39 R40 S42 R44 Q45 T47 N52 R53 S54 S57 R61 K62 Q66 K67 G68 G70 R71 R73 G75 Q81 W82 R83 I87 V88 F89 R94 K99 K102 K103 R105 T135 K150 L164 R167 N168
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:6hma, PDBe:6hma, PDBj:6hma
PDBsum6hma
PubMed
UniProtQ2FW07|RL4_STAA8 Large ribosomal subunit protein uL4 (Gene Name=rplD)

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