Structure of PDB 6fol Chain E Binding Site BS01

Receptor Information
>6fol Chain E (length=150) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GANLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVH
QYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFR
MEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIAR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6fol Chain E Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6fol Molecular recognition and maturation of SOD1 by its evolutionarily destabilised cognate chaperone hCCS.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		H147 H155 H164 D167
Binding residue
(residue number reindexed from 1)		H65 H73 H82 D85
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H130 H132 H147 H155 H164 D167 D201 R224
Catalytic site (residue number reindexed from 1) H48 H50 H65 H73 H82 D85 D119 R142
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006801 superoxide metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6fol, PDBe:6fol, PDBj:6fol
PDBsum6fol
PubMed30735496
UniProtO14618|CCS_HUMAN Copper chaperone for superoxide dismutase (Gene Name=CCS)

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