Structure of PDB 6ff4 Chain E Binding Site BS01

Receptor Information

>6ff4 Chain E (length=130) Species: 9606 (Homo sapiens)

PTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTF
ATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFK
ENDASNIDGFLGPWAKYVDEEEQKELDEIT

Ligand information

>6ff4 Chain 6 (length=95)

gugcucgcuucggcagcacauauacuaaaauuggaacgauacagagaaga
uuagcauggccccugcgcaaggaugacacgcaaauucgugaagcg

<<<<<.<<....>>>>>>>...............................
......<<...<<<.....>>>....>>.................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ff4 Structure and Conformational Dynamics of the Human Spliceosomal BactComplex.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): R130 V167 F168 T170 K180
• Binding residue (residue number reindexed from 1): R48 V85 F86 T88 K98

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003729 mRNA binding
• GO:0005515 protein binding

Biological Process

• GO:0000398 mRNA splicing, via spliceosome
• GO:0006397 mRNA processing
• GO:0008380 RNA splicing
• GO:1990403 embryonic brain development

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005681 spliceosomal complex
• GO:0016607 nuclear speck
• GO:0071007 U2-type catalytic step 2 spliceosome
• GO:0071013 catalytic step 2 spliceosome

External links

• PDB: RCSB:6ff4, PDBe:6ff4, PDBj:6ff4
• PDBsum: 6ff4
• PubMed: 29361316
• UniProt: O60508|PRP17_HUMAN Pre-mRNA-processing factor 17 (Gene Name=CDC40)