Structure of PDB 6evj Chain E Binding Site BS01

Receptor Information
>6evj Chain E (length=749) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPMLIFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVIRTHDYS
SRGIWKTNSETGAQQLNPIDGPLPEDNEPSGYAQTDCVLELIEGLDRSHP
GLFETACQETIDAIQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RKNGYKLNESGRLIDFLKDVLLSFENDSMEVTTHFQKKKRMITQRTIGKK
RVKLTKKNYLIRALTLNTMTKDAERGKLKRRAIATPGMQIRGFVYFVELL
ARNICERLEQSGLPVGGNEKKAKLANVIKKMMAKSTDEELSYTITGDNTK
WNENQNPRIFLAMVLRITAGQPEWFRDLLAVAPIMFSNKVARLGRGYMFE
SKSMHLRTQISAENLSDINLRYFNEDTKKKIEKIRHLMVEGTASLSPGMM
MGMFNMLSTVLGVSVLNLGQREILKRTYWWDGLQSSDDFALIINGHFKED
IQQGVNHFYRTCKLVGINMSQKKSYINKTGTFEFTSFFYRYGFVANFSME
LPSFGVAGNNESADMSIGTTVIKTNMINNDLGPATAQMAIQLFIKDYRYT
YRCHRGDTNLETRRTKSIKRLWTETISKAGLLVADGGPNPYNLRNLHIPE
VCLKWSLMDPDYRGRLCNPNNPFVHHMEVESTNLAVVMPAHGPAKSLEYD
AVATTHSWTPKRNRSILNTNQRGILEDERIYQKCCQVFEKFFPSSTYRRP
IGMASMLDAMLSRARIDARIDLESGRISSQDFSEITNTCKAIEALKRQG
Ligand information
Receptor-Ligand Complex Structure
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PDB6evj Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		N671 R672 S673 I674 N676
Binding residue
(residue number reindexed from 1)		N663 R664 S665 I666 N668
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0005737 cytoplasm
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6evj, PDBe:6evj, PDBj:6evj
PDBsum6evj
PubMed29202182
UniProtH6QM91

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