Structure of PDB 6cpo Chain E Binding Site BS01

Receptor Information

>6cpo Chain E (length=190) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GDTRPRFLWQPKRECHFFNGTERVRFLDRYFYNQEESVRFDSDVGEFRAV
TELGRPDAEYWNSQKDILEQARAAVDTYCRHNYGVGESFTVQRRVQPKVT
VYPSKTQPLQHHNLLVCSVSGFYPGSIEVRWFLNGQEEKAGMVSTGLIQN
GDWTFQTLVMLETVPRSGEVYTCQVEHPSVTSPLTVEWRA

Ligand information

>6cpo Chain F (length=13) Species: 11706 (HIV-1 M:B_HXB2R) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RFYKTLRAEQASQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6cpo CD4+T cell-mediated HLA class II cross-restriction in HIV controllers.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	R13 F26 P56 D57 Y60 W61 I67 Y78 H81 N82 V85
Binding residue (residue number reindexed from 1)	R13 F26 P56 D57 Y60 W61 I67 Y78 H81 N82 V85

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:6cpo, PDBe:6cpo, PDBj:6cpo
PDBsum	6cpo
PubMed	29884618
UniProt	P01911\|DRB1_HUMAN HLA class II histocompatibility antigen, DRB1 beta chain (Gene Name=HLA-DRB1)

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