Structure of PDB 6bw1 Chain E Binding Site BS01

Receptor Information
>6bw1 Chain E (length=426) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS
Ligand information
>6bw1 Chain C (length=8) Species: 928303 (Hendra virus horse/Australia/Hendra/1994) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PPTKKARV
Receptor-Ligand Complex Structure
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PDB6bw1 Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		S105 W142 N146 S149 G150 T151 T155 Q181 W184 N188 G191 D192 N228 W231 R238 W273 Y277
Binding residue
(residue number reindexed from 1)		S34 W71 N75 S78 G79 T80 T84 Q110 W113 N117 G120 D121 N157 W160 R167 W202 Y206
Enzymatic activity
Catalytic site (original residue number in PDB) T151 A163 N361 R366 Q367
Catalytic site (residue number reindexed from 1) T80 A92 N290 R295 Q296
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6bw1, PDBe:6bw1, PDBj:6bw1
PDBsum6bw1
PubMed30209309
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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