Structure of PDB 6bcr Chain E Binding Site BS01

Receptor Information

>6bcr Chain E (length=231) Species: 9606 (Homo sapiens)

MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLLSVAYKN
VVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLEL
LDKYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIDNSQGAYQ
EAFDISKKEMQPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAI
AELDTLNEDSYKDSTLIMQLLRDNLTLWTSD

Ligand information

>6bcr Chain G (length=10) Species: 9606 (Homo sapiens)

SYSNTLPVRK

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6bcr Mechanism of IRSp53 inhibition by 14-3-3.
• Resolution: 1.986 Å
• Binding residue (original residue number in PDB): Y19 S45 K49 N50 G53 R56 S57 R60 K120 R127 Y128 L172 N173 V176 E180 L220 N224
• Binding residue (residue number reindexed from 1): Y19 S45 K49 N50 G53 R56 S57 R60 K120 R127 Y128 L172 N173 V176 E180 L220 N224

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0019904 protein domain specific binding
• GO:0042802 identical protein binding
• GO:0044325 transmembrane transporter binding
• GO:0071889 14-3-3 protein binding

Biological Process

• GO:0006605 protein targeting
• GO:0007165 signal transduction
• GO:0007264 small GTPase-mediated signal transduction
• GO:0008104 protein localization
• GO:0021762 substantia nigra development
• GO:0034766 negative regulation of monoatomic ion transmembrane transport
• GO:0045892 negative regulation of DNA-templated transcription

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005925 focal adhesion
• GO:0016020 membrane
• GO:0032991 protein-containing complex
• GO:0045202 synapse
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:6bcr, PDBe:6bcr, PDBj:6bcr
• PDBsum: 6bcr
• PubMed: 30696821
• UniProt: P27348|1433T_HUMAN 14-3-3 protein theta (Gene Name=YWHAQ)