Structure of PDB 6ahr Chain E Binding Site BS01

Receptor Information
>6ahr Chain E (length=147) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VRFKHRYLLCELVSDDPRCRLSLDDRVLSSLVRDTIARVHGTFGAAACSI
GFAVRYLNAYTGIVLLRCRKEFYQLVWSALPFITYLENKGHRYPCFFNTL
HVGGTIRTCQKFLIQYNRRQLLILLQNCTDEGEREAIQKSVTRSCLL
Ligand information
>6ahr Chain A (length=341) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagggcggagggaagcucaucaguggggccacgagcugagugcguccug
ucacuccacucccaugucccuugggaaggucugagacuagggccagaggc
ggcccuaacagggcucucccugagcuucggggaggugaguucccagagaa
cggggcuccgcgcgaggucagacugggcaggagaugccguggaccccgcc
cuucggggaggggcccggcggaugccuccuuugccggagcuuggaacaga
cucacggccagcgaagugaguucaauggcugaggugagguaccccgcagg
ggaccucauaacccaauucagacuacucuccuccgcccauu
<<.<<<<<<<<<.<..((((.....<<<<..........<<<<.......
.>>>>............>>>>..[...<..<<<<<.....<<<.......
<<<<<.....>>>>><<<<<<<.....>>>>>>><<<<<<<.........
....<<<<<<.<<<<<<.......<<<<<.....<<<<<.<<.<<<<.<<
<....>>>.>>>>>>>>>>>..>>>>>>>>>.>>>>>>>>........>>
>>>>>.>>>....................))))<<<<<<<.<<<<...>>
>>>>>>>>>..]....>>>>>.>.....>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB6ahr Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Resolution3.92 Å
Binding residue
(original residue number in PDB)		R3 K5 R7 Y8 R56 T106 R108
Binding residue
(residue number reindexed from 1)		R2 K4 R6 Y7 R55 T105 R107
Enzymatic activity
Enzyme Commision number 3.1.26.5: ribonuclease P.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004526 ribonuclease P activity
GO:0005515 protein binding
GO:0033204 ribonuclease P RNA binding
Biological Process
GO:0001682 tRNA 5'-leader removal
GO:0006364 rRNA processing
GO:0008033 tRNA processing
Cellular Component
GO:0000172 ribonuclease MRP complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005655 nucleolar ribonuclease P complex
GO:0005730 nucleolus
GO:0030677 ribonuclease P complex
GO:0030681 multimeric ribonuclease P complex
GO:1902555 endoribonuclease complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ahr, PDBe:6ahr, PDBj:6ahr
PDBsum6ahr
PubMed30454648
UniProtQ969H6|POP5_HUMAN Ribonuclease P/MRP protein subunit POP5 (Gene Name=POP5)

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