Structure of PDB 5zms Chain E Binding Site BS01

Receptor Information

>5zms Chain E (length=155) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRL
DPYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGI
FKTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAI
TQGKR

Ligand information

>5zms Chain I (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gKKR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5zms Structures of Zika virus NS2B-NS3 protease in complex with peptidomimetic inhibitors.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	H51 D129 Y130 S135 Y150 G151 N152 G153 Y161
Binding residue (residue number reindexed from 1)	H36 D114 Y115 S120 Y135 G136 N137 G138 Y146

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:5zms, PDBe:5zms, PDBj:5zms
PDBsum	5zms
PubMed	30315877
UniProt	Q32ZE1\|POLG_ZIKV Genome polyprotein

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