Structure of PDB 5z3q Chain E Binding Site BS01

Receptor Information
>5z3q Chain E (length=201) Species: 12081 (Human poliovirus 1 Mahoney) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKHRIEPVCLLVHGSPGTGKSVATNLIARAIAEAENTSTYSLPPDPSHFD
GYKQQGVVIMDDLNQGADMKLFCQMVSTVEFIPPMASLAEAGILFTSNYV
LASTNSSDALARRFAFDMDIQVMNEYSRDGKLNMAMATEMCKNCHQPANF
KRCCPLVCGKAIQLMDKSSRVRYSIDQITTMIINERNRRSNIGNCMEALF
Q
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5z3q Chain E Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5z3q Crystal structure of a soluble fragment of poliovirus 2CATPase
Resolution2.545 Å
Binding residue
(original residue number in PDB)		C269 C272 C281 C286
Binding residue
(residue number reindexed from 1)		C141 C144 C153 C158
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity

View graph for
Molecular Function
External links
PDB RCSB:5z3q, PDBe:5z3q, PDBj:5z3q
PDBsum5z3q
PubMed30231078
UniProtP03300|POLG_POL1M Genome polyprotein

[Back to BioLiP]