Structure of PDB 5z23 Chain E Binding Site BS01

Receptor Information
>5z23 Chain E (length=100) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREICVKFTRGVDFNWQ
AQALLALQEAAEAFLVHLFEDAYLLTLHAKRVTIMPKDIQLARRIRGERA
Ligand information
>5z23 Chain I (length=146) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcaatatccacctgcagattctaccaaaagtgtatttggaaactgctcc
atcaaaaggcatgttcagctgaattcagctgaacatgccttttgatggag
cagtttccaaatacacttttggtagaatctgcaggtggatattgat
Receptor-Ligand Complex Structure
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PDB5z23 The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism.
Resolution2.73 Å
Binding residue
(original residue number in PDB)		H39 R40 Y41 V46 R49 R63 K64 L65 P66 R69
Binding residue
(residue number reindexed from 1)		H2 R3 Y4 V9 R12 R26 K27 L28 P29 R32
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:5z23, PDBe:5z23, PDBj:5z23
PDBsum5z23
PubMed30718488
UniProtP49450|CENPA_HUMAN Histone H3-like centromeric protein A (Gene Name=CENPA);
P68431|H31_HUMAN Histone H3.1 (Gene Name=H3C1)

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