Structure of PDB 5y2z Chain E Binding Site BS01

Receptor Information

>5y2z Chain E (length=467) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLK
TRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSG
SQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIIS
DKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGA
CLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQD
SQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDG
YSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGN
CCNKRDVLCGYLLCTNIGNIPRLGELDGEITSNCSGGHVKLEEDVDLGYV
EDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCV
CNRHWIGSDCNTYFPHN

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

5y2z Chain E Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	5y2z Structural basis of epilepsy-related ligand-receptor complex LGI1-ADAM22.
Resolution	2.67 Å
Binding residue (original residue number in PDB)	E242 D325 C433 N436
Binding residue (residue number reindexed from 1)	E10 D93 C201 N204
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity

	Biological Process
GO:0006508	proteolysis

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5y2z, PDBe:5y2z, PDBj:5y2z
PDBsum	5y2z
PubMed	29670100
UniProt	Q9P0K1\|ADA22_HUMAN Disintegrin and metalloproteinase domain-containing protein 22 (Gene Name=ADAM22)

[Back to BioLiP]