Structure of PDB 5xsq Chain E Binding Site BS01

Receptor Information
>5xsq Chain E (length=312) Species: 482820 (Lake Victoria marburgvirus - Ozolin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVILFDTNHQVSICNQIIDAINSGIDLGDLLEGGLLTLCVEHYYNSDKD
KFNTSPIAKYLRDAGYEFDVIKNADATRFLDVIPNEPHYSPLILALKTLE
STESQRGRIGLFLSFCSLFLPKLVVGDRASIEKALRQVTVHQEQGIVTYP
NHWLTTGHMKVIFGILRSSFILKFVLIHQGVNLDAYDSIISNSVGQTRFS
GLLIVKTVLEFILQKTDSGVTLHPLVRTSKVKNEVASFKQALSNLARHGE
YAPFARVLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQ
LREAAHDAEVKL
Ligand information
>5xsq Chain F (length=23) Species: 482820 (Lake Victoria marburgvirus - Ozolin) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SYMQQVSEGLMTGKVPIDQVFGA
Receptor-Ligand Complex Structure
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PDB5xsq Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide Reveals a Conserved Drug Target for Filovirus
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R206 F207 K214 L217 L221 V228 R235 K247 L250 S251 L253 G257 A260
Binding residue
(residue number reindexed from 1)		R198 F199 K206 L209 L213 V220 R227 K239 L242 S243 L245 G249 A252
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019074 viral RNA genome packaging
Cellular Component
GO:0019013 viral nucleocapsid

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xsq, PDBe:5xsq, PDBj:5xsq
PDBsum5xsq
PubMed28659479
UniProtQ6UY69|NCAP_MABVO Nucleoprotein (Gene Name=NP)

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