Structure of PDB 5wp9 Chain E Binding Site BS01

Receptor Information
>5wp9 Chain E (length=590) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDL
LPRGTGIVTRRPLILQLVHVSQEAEEWGKFLHTKNKLYTDFDEIRQEIEN
ETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIE
LQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAV
ITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIR
DEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAA
QYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGG
ARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSF
ELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDA
IVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADSAREQRDCEV
IERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLL
DDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5wp9 Chain E Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wp9 Structural basis of mitochondrial receptor binding and constriction by DRP1.
Resolution4.22 Å
Binding residue
(original residue number in PDB)		S39 T59
Binding residue
(residue number reindexed from 1)		S39 T59
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008017 microtubule binding
GO:0008289 lipid binding
GO:0016787 hydrolase activity
GO:0030742 GTP-dependent protein binding
GO:0031267 small GTPase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000266 mitochondrial fission
GO:0006816 calcium ion transport
GO:0006897 endocytosis
GO:0007005 mitochondrion organization
GO:0007029 endoplasmic reticulum organization
GO:0010468 regulation of gene expression
GO:0010821 regulation of mitochondrion organization
GO:0012501 programmed cell death
GO:0016559 peroxisome fission
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0048312 intracellular distribution of mitochondria
GO:0048511 rhythmic process
GO:0050714 positive regulation of protein secretion
GO:0051259 protein complex oligomerization
GO:0060047 heart contraction
GO:0070585 protein localization to mitochondrion
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090141 positive regulation of mitochondrial fission
GO:0090149 mitochondrial membrane fission
GO:0160040 mitocytosis
GO:1900063 regulation of peroxisome organization
GO:1901524 regulation of mitophagy
GO:1903578 regulation of ATP metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005903 brush border
GO:0005905 clathrin-coated pit
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030672 synaptic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0032991 protein-containing complex
GO:0043231 intracellular membrane-bounded organelle
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0099073 mitochondrion-derived vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5wp9, PDBe:5wp9, PDBj:5wp9
PDBsum5wp9
PubMed29899447
UniProtO00429|DNM1L_HUMAN Dynamin-1-like protein (Gene Name=DNM1L)

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