Structure of PDB 5onb Chain E Binding Site BS01

Receptor Information
>5onb Chain E (length=269) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAAL
LQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIP
LFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPL
CLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKM
VLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVL
KDDTTTKRWLAQLVKNLQE
Ligand information
>5onb Chain F (length=23) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DDQQLDHNFKQMEEHLALMVEGN
Receptor-Ligand Complex Structure
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PDB5onb DrosophilaBag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E47 H85 N88 Q98 R130 Y134 L137 T138 G141 K148 L177 F184 H231
Binding residue
(residue number reindexed from 1)		E31 H69 N72 Q82 R114 Y118 L121 T122 G125 K132 L161 F168 H215
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0030014 CCR4-NOT complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5onb, PDBe:5onb, PDBj:5onb
PDBsum5onb
PubMed29255063
UniProtQ92600|CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (Gene Name=CNOT9)

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