Structure of PDB 5ona Chain E Binding Site BS01

Receptor Information
>5ona Chain E (length=271) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIA
ALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAH
IPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEII
PLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILG
KMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQ
VLKDDTTTKRWLAQLVKNLQE
Ligand information
>5ona Chain F (length=21) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DQQLDHNFKQMEEHLALMVEG
Receptor-Ligand Complex Structure
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PDB5ona DrosophilaBag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N88 R130 E133 Y134 L137 T138 L177 V181 F184 H231
Binding residue
(residue number reindexed from 1)		N74 R116 E119 Y120 L123 T124 L163 V167 F170 H217
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0030014 CCR4-NOT complex

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Biological Process
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Cellular Component
External links
PDB RCSB:5ona, PDBe:5ona, PDBj:5ona
PDBsum5ona
PubMed29255063
UniProtQ92600|CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (Gene Name=CNOT9)

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