Structure of PDB 5ls6 Chain E Binding Site BS01

Receptor Information

>5ls6 Chain E (length=365) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYEC
HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN
PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV
AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE
SYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCEN
AIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKM
LALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILI
AVCDDASIWRWDRLR

Ligand information

>5ls6 Chain R (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

LQAQRKFAQS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5ls6 Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
Resolution	3.47 Å
Binding residue (original residue number in PDB)	Y148 N307 Y308 C324 I363 W364 Y365 R414
Binding residue (residue number reindexed from 1)	Y72 N231 Y232 C248 I287 W288 Y289 R338

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:5ls6, PDBe:5ls6, PDBj:5ls6
PDBsum	5ls6
PubMed	27739677
UniProt	O75530\|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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