Structure of PDB 5k1a Chain E Binding Site BS01

Receptor Information
>5k1a Chain E (length=222) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FGNTCYCNSVLQALYFCRPFREKVLAYSLLTCLADLFHSIPPKKFHEFLN
YLLNTIADILQEEPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVD
VSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHL
VFPLELRLFDRMYDLVAVVVHCGSGPNRGHYIAIVKSHDFWLLFDDDIVE
KIDAQAIEEFYSGYILFYQSRD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5k1a Chain E Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5k1a Allosteric Activation of Ubiquitin-Specific Proteases by beta-Propeller Proteins UAF1 and WDR20.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C186 C189 C233 C236
Binding residue
(residue number reindexed from 1)		C81 C84 C124 C127
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) C52 H317 D332
Catalytic site (residue number reindexed from 1) C5 H180 D195
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5k1a, PDBe:5k1a, PDBj:5k1a
PDBsum5k1a
PubMed27373336
UniProtO75317|UBP12_HUMAN Ubiquitin carboxyl-terminal hydrolase 12 (Gene Name=USP12)

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