Structure of PDB 5j3h Chain E Binding Site BS01
Receptor Information
>5j3h Chain E (length=271) Species:
9606
(Homo sapiens) [
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GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDECGD
ICNCPATVFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQP
DDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKYVIH
NNKCIPECPSGYTMNSLLCTP
Ligand information
>5j3h Chain B (length=14) Species:
40263
(Endothia gyrosa) [
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SLDESFYDWFERQL
Receptor-Ligand Complex Structure
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PDB
5j3h
Insulin Mimetic Peptide Disrupts the Primary Binding Site of the Insulin Receptor.
Resolution
3.27 Å
Binding residue
(original residue number in PDB)
R14 Q34 L37 F64 F88 F89 Y91 F96 R118 E120 K121
Binding residue
(residue number reindexed from 1)
R10 Q30 L33 F60 F84 F85 Y87 F92 R114 E116 K117
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:5j3h
,
PDBe:5j3h
,
PDBj:5j3h
PDBsum
5j3h
PubMed
27281820
UniProt
P06213
|INSR_HUMAN Insulin receptor (Gene Name=INSR)
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