Structure of PDB 5fi0 Chain E Binding Site BS01

Receptor Information
>5fi0 Chain E (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEFAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVA
DSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNV
FLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGGDIPL
EGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNIN
ETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQE
RAFFLFDNLLVYCKRKSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVT
NGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESL
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain5fi0 Chain E Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5fi0 Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.
Resolution3.282 Å
Binding residue
(original residue number in PDB)		R45 K211
Binding residue
(residue number reindexed from 1)		R11 K173
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:5fi0, PDBe:5fi0, PDBj:5fi0
PDBsum5fi0
PubMed27150042
UniProtQ8TCU6|PREX1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (Gene Name=PREX1)

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