Structure of PDB 5fc8 Chain E Binding Site BS01

Receptor Information

>5fc8 Chain E (length=427) Species: 10090 (Mus musculus)

QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISL
LASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLST
LACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLAD
SCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI
VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI
QQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGL
DKIEALQRHENESVYKASLNLIEKYFS

Ligand information

>5fc8 Chain C (length=13) Species: 11069 (dengue virus type 3)

DYMPSMKRFRKEE

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5fc8 The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): L104 S105 R106 W142 N146 S149 G150 T151 T155 Q181 W184 N188 G191 D192 N228 W231 R238 D270 W273 Y277 N350
• Binding residue (residue number reindexed from 1): L34 S35 R36 W72 N76 S79 G80 T81 T85 Q111 W114 N118 G121 D122 N158 W161 R168 D200 W203 Y207 N280

Enzymatic activity

• Catalytic site (original residue number in PDB): T151 A163 N361 R366 Q367
• Catalytic site (residue number reindexed from 1): T81 A93 N291 R296 Q297

Gene Ontology

Molecular Function

• GO:0061608 nuclear import signal receptor activity

Biological Process

• GO:0006606 protein import into nucleus

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5fc8, PDBe:5fc8, PDBj:5fc8
• PDBsum: 5fc8
• PubMed: 27622521
• UniProt: P52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)