Structure of PDB 5f9h Chain E Binding Site BS01

Receptor Information
>5f9h Chain E (length=638) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKG
KVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENN
DIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYL
DQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIAT
VKHNLEELEQVVYKPQKFFRKVESRIDKFKYIIAQLMRDTESLAKRICRE
FGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDALI
ISEHARMKDALDYLKDFFSNVFDEIEQDLTQRFEEKLQELESVSRDPSNE
NPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLSFLK
PGILTGGDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRGR
ARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILH
IQTHEKFIRDSQEPKPVPDKENKKLLCRKCKALACYTADVRVIEECHYTV
LGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFE
IPVIKIESFVVEDIATVQTLYSKWKDFHFEKIPFDPAE
Ligand information
>5f9h Chain F (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f9h Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		I300 S325 G326 T347 Q349 K379 Q380 H381 Q507 E510 Q511 R546 K635 T636 R637 G663 T697 S698 V718 N720 F853 K888
Binding residue
(residue number reindexed from 1)		I59 S84 G85 T106 Q108 K138 Q139 H140 Q254 E257 Q258 R293 K378 T379 R380 G406 T415 S416 V436 N438 F570 K605
Binding affinityPDBbind-CN: Kd=1.8nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5f9h, PDBe:5f9h, PDBj:5f9h
PDBsum5f9h
PubMed26733676
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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