Structure of PDB 5f9f Chain E Binding Site BS01 |
| >5f9f Chain E (length=672) Species: 9606 (Homo sapiens)
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KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKG
KVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENN
DIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYL
DQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIAT
VKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAKRICK
DREFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYND
ALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQELESV
SRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGN
PKLSFLKPGILTGRGKTNQNTGMTLPAQKCILDAFKASGDHNILIATSVA
DEGIDIAQCNLVILYEYVGNVIKMIQTRGRGRARGSKCFLLTSNAGVIEK
EQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEKFIRDSQEKPKPV
PDKENKKLLCRKCKALACYTADVRVIEECHYTVLGDAFKECFVSRPHPKP
KQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDIATG
VQTLYSKWKDFHFEKIPFDPAE |
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| PDB | 5f9f Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I. |
| Resolution | 2.601 Å |
Binding residue
(original residue number in PDB) | N298 I300 S325 G326 T347 Q349 K379 Q380 H381 Q507 E510 Q511 V514 R546 K635 T636 R637 T662 G663 T667 N668 T697 S698 V718 N720 K750 H830 F853 K858 I875 V886 K888 |
Binding residue
(residue number reindexed from 1) | N57 I59 S84 G85 T106 Q108 K138 Q139 H140 Q257 E260 Q261 V264 R296 K385 T386 R387 T412 G413 T417 N418 T447 S448 V468 N470 K500 H580 F603 K608 I625 V636 K638 |
| Binding affinity | PDBbind-CN: Kd=38.5nM |
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| Enzyme Commision number |
3.6.4.13: RNA helicase. |
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