Structure of PDB 5f98 Chain E Binding Site BS01

Receptor Information
>5f98 Chain E (length=641) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKFPQGQKG
KVVFFANQIPVYEQQKSVFSKYFERHGYRVTGISGATAENVPVEQIVENN
DIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIMFNYL
DQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDASVIAT
VKHNLEELEQVVYKPQKFFRKVESRIDKFKYIIAQLMRDTESLAKRICKR
EFGTQKYEQWIVTVQKACMVFQMPDKDEESRICKALFLYTSHLRKYNDAL
IISEHARMKDALDYLKDFFSNVRAFDEIEQDLTQRFEEKLQELESVSRDP
SNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWIEGNPKLS
FLKPGILTDHNILIATSVADEGIDIAQCNLVILYEYVGNVIKMIQTRGRG
RARGSKCFLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKIL
HIQTHEKFIRDSQEKPKPVPDKENKKLLCRKCKALACYTADVRVIEECHY
TVLGDAFKECFVSRPHPKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKT
FEIPVIKIESFVVEDIATGVQTLYSKWKDFHFEKIPFDPAE
Ligand information
>5f98 Chain F (length=24) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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<<<<<<<<<<....>>>>>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f98 Structural basis for m7G recognition and 2'-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		N298 I300 S325 G326 T347 Q349 I350 K379 Q380 Q507 K635 T636 R637 T662 T697 S698 K750 H830 F853 S854 K858 K888 S906 W908
Binding residue
(residue number reindexed from 1)		N57 I59 S84 G85 T106 Q108 I109 K138 Q139 Q255 K381 T382 R383 T408 T416 S417 K469 H549 F572 S573 K577 K607 S625 W627
Binding affinityPDBbind-CN: Kd=1.7nM
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:5f98, PDBe:5f98, PDBj:5f98
PDBsum5f98
PubMed26733676
UniProtO95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)

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