Structure of PDB 5esv Chain E Binding Site BS01

Receptor Information
>5esv Chain E (length=176) Species: 11676,71421 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLIRIGHGFDVHAFGCVTLNCSDAKVNINREEIKNCSFNATTELRDKKKK
EYALFYRLDIVPLNNSEYRLINCNGGDVALHALTDAILGAAALGDIGNAD
SRGLLREAFRQVQEKGYKIGNVDITIIAQAPPHIDAMRAKIAEDLQCDIE
QVNVKATTTEIACEAVALLIRQGLEV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5esv Chain E Residue 422 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5esv Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design.
Resolution3.105 Å
Binding residue
(original residue number in PDB)		D120 H122 H207
Binding residue
(residue number reindexed from 1)		D10 H12 H81
Annotation score1
Enzymatic activity
Enzyme Commision number 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
Gene Ontology
Molecular Function
GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process
Cellular Component
GO:0019031 viral envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5esv, PDBe:5esv, PDBj:5esv
PDBsum5esv
PubMed26689967
UniProtP44815|ISPF_HAEIN 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Gene Name=ispF);
W6ICC0

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