Structure of PDB 5ei9 Chain E Binding Site BS01

Receptor Information
>5ei9 Chain E (length=111) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EKPYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRDKSHLLRH
QRTHTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNK
SHLLRHQRTHT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ei9 Structural basis for human PRDM9 action at recombination hot spots.
Resolution1.921 Å
Binding residue
(original residue number in PDB)		R726 R736 H737 T740 R754 F756 H761 R764 H765 T768 R782 R785 N789 H793 T796 R810 F812 N814 H817 R820 H821 T824
Binding residue
(residue number reindexed from 1)		R11 R21 H22 T25 R39 F41 H46 R49 H50 T53 R67 R70 N74 H78 T81 R95 F97 N99 H102 R105 H106 T109
Binding affinityPDBbind-CN: Kd=36nM
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
External links
PDB RCSB:5ei9, PDBe:5ei9, PDBj:5ei9
PDBsum5ei9
PubMed26833727
UniProtQ9NQV7|PRDM9_HUMAN Histone-lysine N-methyltransferase PRDM9 (Gene Name=PRDM9)

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