Structure of PDB 5eh2 Chain E Binding Site BS01

Receptor Information
>5eh2 Chain E (length=110) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPYVCRECGRGFSNKSHLLRHQRTHTGEKPYVCRECGRGFRDKSHLLRHQ
RTHTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNKS
HLLRHQRTHT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5eh2 Structural basis for human PRDM9 action at recombination hot spots.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		R726 H733 R736 T740 F756 H761 R764 H765 T768 R782 R785 N789 H793 R810 F812 N814 H817 R820 H821
Binding residue
(residue number reindexed from 1)		R10 H17 R20 T24 F40 H45 R48 H49 T52 R66 R69 N73 H77 R94 F96 N98 H101 R104 H105
Binding affinityPDBbind-CN: Kd=28nM
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
2.1.1.355: [histone H3]-lysine(9) N-trimethyltransferase.
2.1.1.359: [histone H3]-lysine(36) N-trimethyltransferase.
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
2.1.1.362: [histone H4]-N-methyl-L-lysine(20) N-methyltransferase.
External links
PDB RCSB:5eh2, PDBe:5eh2, PDBj:5eh2
PDBsum5eh2
PubMed26833727
UniProtQ9NQV7|PRDM9_HUMAN Histone-lysine N-methyltransferase PRDM9 (Gene Name=PRDM9)

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